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Alan Guttmacher, MD
Director, Eunice Kennedy Institute of Child Health and Human Development
National Institute of Health
Title: "A Vision for the Future of Perinatal Research"
Moderator: Stacy Zamudio, PhD
6:30 p.m.- 7:30 p.m.
Dinner - With introduction of Trainees by Drs. Lane, Zamudio and Buhimischi
7:45 p.m.- 8:45 p.m.
MEAD-JOHNSON NUTRITIONAL LECTURER
J. Lee Nelson, MD
University of Washington
Professor, Research in Autoimmunity
Human Immunogenetics Laboratory
Fred Hutchinson Cancer Research Center
Title: "The legacy of pregnancy: microchimerism for better or for worse"
Saturday, Sept. 21, 2013
7:00 a.m. - 8:00 a.m.
8:00 a.m. - 9:00 a.m.
MARCH OF DIMES LECTURER
Lisa Robinson, MD, FRCP
Canada Research Chair in Leukocyte Migration in Inflammation and Injury
Division Head, Nephrology
Sick Kids Hospital, Toronto, Ontario, Canada
Title: "Leukocyte Trafficking in Inflammation: Links to the Developing Brain"
9:00 a.m. -10:00 a.m.
Ronald Wapner, MD
Professor, Obstetrics / Gynecology
Vice Chairman of Research
Director of Reproductive Genetics
Columbia University Medical Center
Title: "Transitioning Microarray Technology from the Bench to Bedside"
10:00 a.m. - 10:30 a.m.
10:30 a.m. -11:30 a.m.
MEAD-JOHNSON NUTRITIONAL EARLY CAREER INVESTIGATOR SPEAKER PRESENTATIONS
Helen Jones, PhD
Assistant Professor, Division of Pediatric Surgery & Reproductive Sciences
Cincinnati Children's Hospital Medical Center
Title: Placental Abnormalities in Hypoplastic Left Heart Syndrome
Sally Collins, MD, PhD
Maternal-Fetal Medicine Trainee, John Radcliffe Hospital, Oxford, UK
Clinical Fellow - Nuffield Department of Obstetrics & Gynecology
University of Oxford, UK
Title: Developing Ultrasound Techniques for Pregnancy Related Disorders: Acoustic Answers to Placental Problems?
11:30 a.m. -12:30 p.m.
ABBOTT NUTRITION LECTURER Paulo Rinaudo, MD, PhD
University of California - San Francisco
Title: "Preimplantation Disturbance and Long Term Health"
12:30 p.m.- 1:30 p.m.
1:30 p.m.- 3:00 p.m.
3:00 p.m.- 4:00 p.m.
4:00 p.m.- 5:00 p.m.
Sandra T. Davidge, PhD
Director, Women and Children's Health Research Institute
Professor, Departments OB/GYN and Physiology
Canada Research Chair (Tier 1) in Women's Cardiovascular Health
Alberta Heritage Foundation for Medical Research Scientist
Title: "Are There Interventions to Rescue a Fetal Programmed Phenotype?"
5:00 p.m.- 6:00 p.m.
ABBOTT NUTRITION EARLY CAREER INVESTIGATOR SPEAKER PRESENTATIONS
Trent Tipple, MD
Assistant Professor, Division of Neonatology
Nationwide Children's Hospital & The Ohio State University College of Medicine
Title: "An Antioxidant Paradox: Inhibition of
Thioredoxin Reductase to Prevent Bronchopulmonary Dysplasia"
Stephanie Thorn, PhD
Department of Pediatrics
University of Colorado Anschutz Medical Campus
Title: "Fetal Metabolic Adaptations: From Nutrient
Restriction to Maternal Obesity"
6:00 p.m. - 7:00 p.m.
Sunday, Sept. 22, 2013
7:00 a.m. - 8:00 a.m.
8:00 a.m. - 9:00 a.m.
Mala Mahendroo, PhD
Department of Obstetrics / Gynecology
University of Texas Southwestern Medical Center
Title: “Cervical Remodeling in Term and Preterm Birth: New Insights into Distinct Mechanisms”
9:00 a.m. - 10:00 a.m.
Surendra Sharma, MD, PhD
Research Scientist, Professor
Warren Alpert Medical School
Brown University, Providence, RI
Title "New Mechanistic/Therapeutic Options for Preeclampsia"
10:00 a.m. - 10:15 a.m.
10:15 a.m. -11:15 a.m.
YOUNG INVESTIGATOR AWARDS AND ACKNOWLEDGEMENTS
Lisa Joss-Moore, PhD
Department of Pediatrics
University of Utah Salt Lake City
Early Career Speaker Bios -
Helen Jones Ph.D. is currently an Assistant Professor in the Divisions of Pediatric Surgery and Reproductive Sciences at Cincinnati Children's Hospital Medical Center. She received her undergraduate degree from the University of St. Andrews and her Ph.D from the Rowett Institute of Nutrition and Health, University of Aberdeen, Scotland. Dr. Jones undertook a postdoctoral fellowship in placental function in maternal Obesity with Drs Jansson and Powell at the University of Cincinnati. Her main research interests lie in placental structure and function in fetal growth restriction and Hypoplastic Left Heart Syndrome and the development of nanoparticle-gene therapy to improve placental growth and function.
Sally Collins, MD PhD, is currently a sub-specialty trainee in Maternal Fetal Medicine at the John Radcliffe Hospital in Oxford, UK and a Clinical Fellow in the Nuffield Department of Obstetrics and Gynaecology, University of Oxford. Originally training as a professional actress, Sally came late to her career in medicine. She graduated in Clinical Medicine from the University of Oxford and specialised in Obstetrics, training within the Oxford Deanery. She recently completed a PhD in Obstetric Ultrasound. Her work used 2D and 3D ultrasonography to explore the vasculature and morphology of the developing placenta with the aim of developing a screening test for fetal growth restriction. The thesis also examined the research methodology currently employed for power Doppler ultrasonographic techniques. Work from her PhD resulted in two international research awards, several papers and a patent. Her current research continues to focus on novel placental ultrasound techniques including developing a novel 3D power Doppler imaging technique for diagnosing the abnormally invasive placenta and quantifying the clinical risk it poses.
Trent Tipple, MD is currently an Assistant Professor of Pediatrics in the Division of Neonatology at Nationwide Children's Hospital & The Ohio State University College of Medicine in Columbus, OH. He is also a principal investigator in the Center for Perinatal Research at The Research Institute at Nationwide Children's Hospital. Dr. Tipple performed his undergraduate studies at Butler University, received his medical degree from Indiana University, and completed his pediatric residency and neonatal-perinatal medicine fellowship training at Columbus (now Nationwide) Children's Hospital. Dr. Tipple's long-term research goal is to develop clinically useful therapies that prevent the development of bronchopulmonary dysplasia. His areas of research expertise include redox biology, oxidant lung injury, and neonatal lung development. Previous published work by Dr. Tipple has revealed that inhibition of the redox enzyme thioredoxin reductase protects against hyperoxic lung injury, likely through the induction of endogenous pulmonary antioxidant responses. His current research is focused on determining the safety and efficacy of thioredoxin reductase inhibition as a novel therapeutic approach to attenuate oxygen-mediated neonatal lung injury.
Stephanie Thorn, PhD is currently an Assistant Professor in the Department of Pediatrics, University of Colorado Anschutz Medical Campus. She received her PhD from Cornell University and completed her postdoctoral training at the University of Colorado. Dr. Thorn is interested in understanding how the fetus responds to altered nutrient supply and how these changes in fetal metabolism may persist after birth and increase susceptibility to adult metabolic disease. Her primary research is aimed to understand the effects of intrauterine growth restriction (IUGR) using a sheep model and integrative approaches in physiology and metabolism combined with novel molecular techniques in cell biology, epigenetics, and metabolomics. She is also involved in a collaborative project investigating the effects of maternal high fat diet and obesity on offspring metabolism in a nonhuman primate model.
Named Sponsorship Speaker Bios -
Alan E. Guttmacher, MD is the Director of the Eunice Kennedy Shriver National Institute of Child Health and Human Development, the focal point at the National Institutes of Health for research in pediatric health and development, maternal health, reproductive health, intellectual and developmental disabilities, and rehabilitation medicine.
A pediatrician and medical geneticist, Dr. Guttmacher previously was at the National Human Genome Research Institute, where he served in several roles, including Deputy Director and Acting Director, overseeing that institute's efforts to advance genome research, integrate that research into health care, and explore the ethical, legal, and social implications of human genomics.
A graduate of Harvard College and Medical School, Dr. Guttmacher completed an internship and residency in Pediatrics and a fellowship in Medical Genetics at Harvard and Children's Hospital of Boston. He is a member of the Institute of Medicine.
J. Lee Nelson, MD
is a member of the Fred Hutchinson Cancer Research Center and Professor of Medicine at the University of Washington. She heads a research group that has an overall goal of elucidating the beneficial and detrimental effects of maternal-fetal cell exchange during and subsequent to pregnancy. Dr. Nelson began her work investigating immunological changes that occur during pregnancy and described fetal-maternal HLA-disparity in the pregnancy-induced amelioration of rheumatoid arthritis. She later spearheaded a new area of research examining the long-term consequences of naturally acquired microchimerism, with initial studies focused on systemic sclerosis (scleroderma). Microchimerism refers to harboring a small number of cells (or DNA) that originated in a genetically disparate individual. The most common sources of microchimerism are maternal cells in her progeny and cells of fetal origin in women who have been pregnant. The research team she leads is interdisciplinary and studies microchimerism in autoimmune diseases, cancer and pregnancy complications.
Lisa Robinson, MD, FRCPis an Associate Professor in Pediatrics at the University of Toronto, Head of the Division of Nephrology at The Hospital for Sick Children (SickKids), a Senior Scientist in the Cell Biology program at the SickKids Research Institute, and a Canada Research Chair in Leukocyte Migration in Inflammation and Injury.
Dr. Robinson attended medical school at the University of Toronto, trained in Internal Medicine at Toronto General Hospital, and completed her residency in Pediatrics at the University of Western Ontario. She received her Paediatric Nephrology training at Duke University and during this time she pursued basic research training in the Departments of Immunology and Medicine, focused on exploring the mechanisms whereby leukocytes traffic within inflamed tissues. Her basic and translational research program has 2 areas of focus: 1) understanding the regulation of expression and function of chemokines and adhesion molecules in inflammation, and 2) exploring the role of neuronal guidance cues in attenuating inflammation and thrombosis. Her research program integrates molecular biology, cell biology, advanced microscopic, and biochemical approaches with animal models of inflammation and renal injury.
Dr. Robinson is the founder and director of Kids Science, a SickKids Research Institute program which provides opportunities for middle- and high-school students to improve their understanding of science and technology, and to make positive educational and career choices. Kids Science targets “at-risk” youth who do not have equal exposure to science and technology awareness experiences, including patients with chronic illnesses at SickKids, students from Northeastern Ontario, and students from Toronto inner-city schools.
Ronald Wapner, MD is currently the Vice-Chair for Research in Obstetrics and Gynecology for Columbia University Medical Center and Director of Reproductive Genetics.
Dr. Wapner is an internationally known physician and researcher specializing in reproductive genetics. He pioneered the development of chorionic villus sampling (CVS) and multi-fetal reduction. He has authored or co-authored over 250 publications and he has been an active investigator in the area of Maternal-Fetal Medicine. He is either a principal or co-investigator for a number of NICHD sponsored multi-center studies. He serves as the center PI for the National Standards for Fetal Growth study and the NuMoM2B study at Columbia University in the Maternal Fetal Medicine Units Network.
Most recently, Dr. Wapner led a multicenter study evaluating the accuracy, efficacy and clinical advantages of prenatal diagnosis using microarray analysis. He has had a significant role in the development of multidisciplinary research studies and clinical research centers throughout his career.
Paulo Rinaudo, MD, PhD, FACOG is currently an Associate Professor in the Department of Obstetrics, Gynecology and Reproductive Sciences at the University of California San Francisco campus.
Dr. Rinaudo earned his MD from Torino Medical School and his PhD in Biology from Torino University, Torino, Italy. He then completed his MD residency in Obstetrics/ Gynecology at Yale University and
Fellowship in Reproductive Endocrinology and Fertility at the University of Pennsylvania. The focus of Dr. Rinaudo's laboratory at UCSF is to understand how in vitro fertilization (IVF) and in vitro culture prior to implantation in the uterus of the mother affect fetal and adult development. Dr. Rinaudo is a frequent national and international invited presenter on his work in addition to his membership in multiple professional organizations including the American Soceity of Reproductive Medicine (ASRM), European Soceity of Human Reproduction and Embryology (ESHRE), Society for Gynecologic Investigation (SGI) and Society for the Study of Reproduction (SSR).
Sandra T. Davidge, PhD is the Director of the Women and Children's Health Research Institute (WCHRI) at the University of Alberta. She is Professor in the Departments of Obstetrics & Gynecology and Physiology at the University of Alberta and holds a Tier 1 Canada Research Chair in Women's Cardiovascular Health. Dr. Davidge serves on numerous scientific committees in the United States and Canada. She is past President of the North American Perinatal Research Society (2006-2007). She also serves on many national and international grant panels and is on the editorial board for a number of journals including Hypertension and American Journal of Physiology. Dr. Davidge's research program is focused on women's cardiovascular and reproductive health. Her research program encompasses studying vascular function as it relates to 1) complications in pregnancy (preeclampsia), 2) hormonal status (ie pregnancy and menopause) and 3) fetal origins of adult cardiovascular diseases. The Davidge research program focuses on common vasoactive mediators altered by pro-oxidants in these conditions that are unique to the reproductive stage of women. The Davidge laboratory combines their expertise in pregnancy research and aging to understand long-term consequences of an adverse pregnancy on cardiovascular health of the offspring as they age. She has published over 160 peer-reviewed manuscripts in these areas and continues to be funded by Canadian Institutes of Health Research. Dr. Davidge's research has been recognized for Excellence in Research with the Martha Cook Piper Award at the University of Alberta and the President's Scientific Achievement Award from the international Society Gynecologic Investigation She was recently awarded the Academic Leadership Award from the College of Agricultural, Human and Natural Resources (2011) and the Distinguished Graduate from the Animal Science Department (2012) from Washington State University.
Mala Mahendroo, PhD is an Associate Professor in the Department of Obstetrics and Gynecology and The Green Center for Reproductive Biological Sciences at the University of Texas Southwestern Medical Center in Dallas, TX. Trained in the field of molecular biology, Dr. Mahendroo is a well recognized leader in studies focused on the molecular mechanisms of cervical remodeling in preparation for term birth as well as preterm birth. Her studies using the mouse as a model system, employ molecular, cell biology and physiological approaches to elucidate the dynamic process by which the cervix remodels in preparation for parturition. Additionally she is involved in collaborative translational studies focused on the development of imaging tools for assessment of premature cervical ripening. Her work is supported by the NIH and a Burroughs Welcome Fund Prematurity Research Initiative Award. She is an active member of the Integrative Biology Graduate program at UTSW as well as involved in training of MFM Fellows in basic research.
Surendra Sharma, MD, PhD is Professor of Pediatrics and Co-Director of the Perinatal Biology Center for Biomedical Research Excellence. The research focus in Dr. Sharma's laboratory is to identify functional biomarkers and to establish in vitro and in vivo models for adverse pregnancy outcomes and their application to intergenerational impacts. He has a broad background in immunology, molecular biology, placental biology, cytokines, hormones, mouse and human models of pregnancy, and analysis of functional biomarkers for adverse pregnancy outcomes with a focus on preterm birth. He has been the recipient of numerous grants from NIH, NIEHS, American Diabetes Association, and the Rhode Island Science and Technology Council. He has served as a member of NIH and ADA review panels. Dr. Sharma has been a mentor to numerous PhD, Post-doctoral, and clinical fellows. He recently completed his tenure as President of the American Society for Reproductive Immunology (2010-2012). Dr. Sharma was the recipient of the 2007 Blackwell Munksgaard Award for outstanding research in Reproductive Immunology. Dr. Sharma's lab has recently established serum-based "humanized" mouse models and in vitro predictive assays for pregnancy complications. His lab has extensively published on the role of IL-10 in pregnancy and demonstrated that IL-10 deficient mice are uniquely sensitive to inflammatory triggers that cause fetal resorption, preterm birth, and preeclampsia. He has collaborated with clinicians and basic scientists to move forward the cutting edge concepts concerning adverse pregnancy outcomes. His published and unpublished work has unraveled intriguing in utero and anti-angiogenic properties of dysregulated proteins in patients experiencing preterm labor, preeclampsia and gestational diabetes. The studies proposed for the March of Dimes prematurity initiative are an obvious and exciting extension of previous and ongoing research in his laboratory.
Lisa Joss-Moore, PhD began a faculty appointment with the Department of Pediatrics, University of Utah in 2007. Her research focus is the Developmental Origins of Lung Disease. Specifically, Dr. Joss-Moore examines the molecular mechanisms driving alveolar formation and how these mechanisms are perturbed by perinatal insults. A major theme is the role of the transcription factor, PPARgamma, in maintaining the epigenetic integrity of the lung. Her studies involve molecular, morphometric and physiologic approaches. The effects of the omega-3 fatty acid, DHA, on PPARgamma in the lung are also being examined. Her studies involve molecular, morphometric and physiologic approaches. Dr. Joss-Moore's research is supported by the NIH. As Associate Director for Research for the Neonatal-Perinatal Fellowship program, Dr. Joss-Moore also mentors and instructs Fellows on aspects of academic research including scientific approaches, methods, scientific writing and presenting.
Please feel free to contact Dr. Ian Bird, PhD via e-mail at firstname.lastname@example.org if you have any questions. Click here for the PRS Reimbursement Policies.