Tag Archives: PRS

Meeting Program 2022

September 9-11

Sonesta Bee Cave Hotel, Austin, TX

“Translation through Collaboration”

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Friday, Sept 9 
5:30 pmWelcome Reception Followed by Dinner 
7:00 pmWelcome by PRS President, Laura Brown, MD

7:30 pm

March of Dimes Speaker: Laurie Goodyear, PhD

“Mechanisms Underlying the Beneficial Effects of Maternal Exercise on Offspring Health”
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Saturday, Sept 11

8:00 – 8:45 amLiley Award Winner: Yoel Sadovsky, MD “New Insights into Placental Fat Control”

9:00 – 9:45 amUniversity of Colorado Speaker: Leslie Leinwand, PhD

“Redefining Snake Oil: Novel Biology Could Lead to New Therapeutics in Humans”

10:15 – 11:00 am

NICHD Speaker (Virtual): Myriam Hemberger, PhD

Remote Presentation

“The Under-Estimated Role of the Placenta on Developmental Outcome and Congenital Defects”

 

11:15 – 11:30 am

Burroughs Wellcome Fund PRS Early Career Speaker: Angela Maria Gonella, PhD

“Metabolomic Composition of the Oviductal Fluid in High vs Low Receptivity Cows: What the Embryo Needs to Survive”

1:00 – 2:00 pmBusiness Meeting 
2:00 – 2:20 pmReckitt/Mead Johnson Nutrition PRS Early Career Speaker: Michelle Vaz, MD

“Elucidating the Role of Group B Streptococcus Capsular Serotype in a Murine Model of Intestinal Colonization”

2:30 – 2:50 pmReckitt/Mead Johnson Nutrition PRS Early Career Speaker: Leah Habersham, MD, MBS, MS“Bridging OB-GYN and Addiction Medicine Through a Lens of Health Equity”

Sunday, September 11

8:00 – 8:45

Burroughs Wellcome Fund Speaker: Tracy Bale, PhD

“The Functional Role of Placental EVs in Maternal Metabolic Health and Fetal Development”

9:00 – 9:45 amNICHD Speaker: Andrew Wolfe, PhD (NIH/NICHD)

“Ins and Outs of NIH Peer Review”

10:00 – 10:45 amReckitt/Mead Johnson Nutrition Speaker: Andrea Edlow, MD, MSc“COVID-19 and COVID Vaccines in Pregnancy and Lactation: What We Know Now”

11:00 – 11:45 amPRS Member Speaker: Krithika Lingappan, MD, PhD“Resilience of the Premature Baby Girl in the NICU: Insights from the Developing Lung”

Memories of 2022

PRS 50th “Anniversary Fundraising Donations”

To celebrate the 50 Anniversary of the Perinatal Research Society, we have initiated a fundraising effort to support the PRS Educational Fund. Proceeds from this account are used to fund programs designed to support the careers of young investigators and trainees including the Young Investigator Grant Writing Program, the Associate Member Prize, and the PRS-PSANZ Mont Liggins Early Career Award.

Our ultimate goal is to grow the proceeds in our “endowment-style” fund to ensure that PRS can maintain and grow educational programming in the event of reduced external funding.

In order to accomplish this goal, we need to grow the PRS Educational Fund to $300,000*

We sincerely hope that you will help contribute to long term success of the educational mission of the Perinatal Research Society as we enter the next 50 years.

*PRS is a registered 501c3 charitable organization and all contributions are tax deductible. You will receive a confirmation letter from PRS indicating this.

To make a donation, please click below:

Make a Donation

Honoring Young Investigator Success Stories

Basic Track

Mary Wallingford, PhD, is a PRS young investigator in the basic track. Dr. Wallingford’s new lab at Tufts Medical Center investigates mechanisms that control placental vascular development and pathophysiology. Her group combines classic embryology and cutting edge vascular biology bioengineering techniques in an innovative, interdisciplinary approach that is very well supported in the expanding Mother Infant Research Institute (MIRI) [please link to https://www.tuftsmedicalcenter.org/Research-Clinical-Trials/Institutes-Centers-Labs/Mother-Infant-Research-Institute/Overview] at Tufts Medical Center

Dr. Wallingford first joined PRS as a 2017 NIH Young Investigator at the 48th Annual PRS Meeting where she participated in the Young Investigator Grant Writing Workshop.  Dr. Wallingford participated in the workshop at a truly pivotal time in her career as she was conducting research on her K99, developing her independent research plan, and interviewing with several exceptionally strong research institutions.  She has shared that the Young Investigator Grant Writing Workshop “was an extremely unique and valuable experience that I recommend to all postdocs and early career PIs!  In fact, I would love to adapt the combined didactic/writing model that the workshop used to other professional development programs that I participate in – opportunities in the developmental biology and vascular biology research communities, for example. ”

To discuss the workshop or her lab’s placenta vascular biology research [Please link to https://www.tuftsmedicalcenter.org/Research-Clinical-Trials/Institutes-Centers-Labs/Mother-Infant-Research-Institute/Laboratories/Wallingford-Lab] with Dr. Wallingford, please feel free to contact her at mwallingford@tuftsmedicalcenter.org.

OB Track

Jackie Parchem, MD is an Assistant Professor in the OB/GYN Department at the University of Texas Health Science Center at Houston (UTHealth). She chose to subspecialize in Maternal-Fetal Medicine in part due to a long-standing interest in human development and the biology of pregnancy. Jackie relocated from San Francisco to Houston with her family in 2015. She joined Raghu Kalluri’s lab at the MD Anderson Cancer Center to study the biology of exosomes in pregnancy. Jackie attended the PRS Grant Writing Workshop and Annual Meeting for the first time this year with encouragement from Laura Goetzl. In addition to working on grantsmanship with an experienced group of PRS faculty mentors, she enjoyed meeting with old and new friends, and has since joined PRS as an Associate Member. She was recently awarded a career development grant from the Society for Maternal-Fetal Medicine. Jackie has two daughters, ages 4 and 1, with her husband who is a developmental neuroscientist at Baylor College of Medicine.

 

Pediatric Track

Tomo Tarui, MD is an Assistant Professor of Pediatrics and Neurology at Tufts University School of Medicine and Director of the Fetal-Neonatal Neurology Program at the Floating Hospital for Children. Dr. Tarui has a unique clinical expertise and has been actively involved in the prenatal diagnosis and management of fetal neurological disorders as well as long-term follow up after birth.

Dr. Tarui completed his training in Child Neurology Residency and subsequent Fetal Neonatal Neurology Fellowship at Boston Children’s Hospital, Boston MA. After became a faculty at Tufts Medial Center, Dr. Tarui has been pursuing his K23 project “Prenatal diagnosis of brain malformations: Improving assessment of prognosis.” under the mentorship of Drs. Diana Bianchi, Ellen Grant and Donna Slonim. His research has been focused on development of novel diagnostic and therapeutic technologies for fetal and neonatal neurological disorders. In his K project, Dr. Tarui has been developing unique scientific skills in fetal and neonatal neuroimaging research (quantitative analysis of fetal and neonatal MRIs) and genomic research (transcriptomics of fetal neonatal neurological disorders). Dr. Tarui had a great opportunity to participate in Perinatal Research Society, NIH Abbott Grant Writing Workshop/Young Investigator Program in September 2017. Dr. Tarui had privileged opportunity to learn great wisdom of grant writing, oral presentation and scientific figure preparation as well as seeking advice from the world experts in perinatal research. Using the training he obtained from the Workshop, Dr. Tarui was able to publish two peer-reviewed articles, prepare two manuscripts in work, submit three grant proposals, present an oral presentation at the World Congress of International Society of Ultrasound in Obstetrics and Gynecology (Singapore), and two posters at Pediatric Academic Society (Toronto) and International Symposium on Fetal Brain (Washington DC). Currently, Dr. Tarui is preparing for his first R01 proposal to bring up his research to the next translational stage.

Meeting Program 2021

September 10-12

Sirata Beach Resort, St Pete’s Beach, Florida, Brooklyn

“Translation through Collaboration”

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Friday, Sept 10th  
5:30 pmWelcome Reception Followed by Dinner 
7:00 pm Welcome by PRS President, Irina Burd, MD, PhD

 

7:30 pm

Liley Award Winner: Rebecca Simmons, MD

Perinatal Research: Life in the Fast Lane, Life in the Slow Lane”

 

Saturday, Sept 11

  
8:00 – 8:45 amBurroughs Wellcome Fund Speaker: Louis Muglia, MD, PhD, President & CEO, Burroughs Wellcome Fund“The Burroughs Wellcome Fund and Perinatal Research: Mission, Priorities and Opportunities”

 

 

9:00 – 9:45 amJohns Hopkins Dept of Gynecology & Obstetrics Speaker: Paul Rozance, MD

“Uncovering a Novel Fetal to Maternal Signaling Pathway for the Homeostatic Regulation of Intrauterine Growth through Collaborative Science”

 

10:15 – 11:00 am

March of Dimes Speaker: Laura Ensign-Hodges, PhD

Remote Presentation

“Nanomedicine for Preterm Birth Prevention”

 

 

11:15 am – 12 pm

Mead Johnson Nutrition Speaker: David Aronoff, MD

Remote Presentation

“Host-microbe Intonations in the Pathogenesis of Bacterial Chorioamnionitis”

 

 

12: 15 – 12:35 pmBurroughs Wellcome Fund PRS Early Career Speaker: Leena Kadam PhD“Senescence Pathways in Trophoblast Differentiation”

 

 

1:30 – 2:30 pmBusiness Meeting  
2:30 – 2:50 pmMeade Johnson Nutrition PRS Early Career Speaker: Sarah Wernimont, MD, PhD

“Mitochondrial Macronutrient Flux and Regulation of Syncytiotrophoblast Differentiation”

3:00 – 3:20pmMead Johnson Nutrition PRS Early Career Speaker: Vivek Shukla, MD“Advanced Machine Learning Based Prediction of Perinatal Outcomes”

 

 

Sunday, September 12

  
8:00 – 8:45 pm

NICHD Presentation: Nahida Chaktura, MD

Remote Presentation

“NICHD Perspective and Research Priorities”

9:00 – 9:45 amBurroughs Wellcome Fund Speaker: Courtney Townsel, MD

Title: Immunoperinatology: Placental determinants of neonatal health and disease

10:15 – 11:00 amMarch of Dimes Speaker: Les Myatt, PhD, FRCOG“Sexual Dimorphism of Placental Function: Relationship to Fetal Development and Pregnancy Outcomes”

 

11:15 am – 12:00 pmPRS Member Speaker: Laura Goetzl, MD, MPH“Translational Potential of Neuronally-Derived Exosomes: Call for Collaboration”

 

 

Memories of 2021

Meeting Program 2019

50th Annual Meeting

September 27-29, 2019

Minneapolis Marriott Northwest, Brooklyn Park, MN

Overall Meeting Theme(s)

  1. “Bench to Bedside” – the continuum of research contributions from PRS members
  2. Celebrate the success of the Society over 50 years
Friday, September 27 – Dinner & Speaker
Time Speaker Title/brief description of topic Location
3:00 – 6:00 pm   CHECK-IN AND REGISTRATION  
530 pm Welcome Reception Followed by Dinner    
7:00 pm Welcome by PRS President Lisa Joss-Moore, PhD  
7:30 pm NICHD Presentation A moderated presentation celebrating the Perinatal Research Society, its first 50 years, and the future  
       

Saturday, September 28

     
Time Speaker Title/brief description of topic Location
6:45 – 7:45 am Breakfast    
8:00 – 8:45 am University of Utah OB Speaker   – Sandra T. Davidge, PhD, FAAP Title: Impact of pregnancy complications on later life cardiovascular health in the offspring- what can we do about it?”

 

Pregnancy is a window to assess cardiovascular health and can impact later-life maternal and offspring cardiovascular health, thus impacting future generations. Dr. Davidge’s research is focused on understanding mechanisms for vascular complications of pregnancy (e.g. preeclampsia, maternal aging) and developmental origins of cardiovascular disease. The impact of this research is to ultimately develop novel therapeutic strategies to improve pregnancy outcomes and minimize the impact of pregnancy complications on both maternal and offspring cardiovascular health.

 
8:45 – 9:00 am Questions and Answers    
9:00 – 9:45 am University of Utah Pediatrics Speaker – David Stevenson, MD

Title: Understanding Disparities in Preterm Birth.  “New insights into the immunologic and signaling processes that determine gestational length in pregnancy have revealed important complexity in the interactions (ancestral and current) between genetic and environmental forces.  A better understanding of these relationships could guide research efforts which, in turn, could lead to a reduction in disparities in preterm birth by introducing effective clinical and public health interventions.” 

 

 
9:45 – 10:00 am Questions and Answers    
10:00 – 10:15 am BREAK    
10:15 – 11:00 am March of Dimes Speaker – Patrick Catalano, MD

Title: Maternal obesity and gestational diabetes; short and long term effects on the offspring.  Maternal obesity and diabetes have independent effects on fetal growth.  Long-term, maternal gestational diabetes is associated primarily with childhood glucose metabolism, while maternal obesity is primarily associated with childhood adiposity.

 
11:00 – 11:15 am Questions and Answers    
  Abbott Nutrition Early Career Speakers    
 

 

11:15 – 11:35 am

PRS-PSANZ Early Career Speaker – Tayla Penny  Title:  Repeated doses of umbilical cord blood cells modulate perinatal brain injury.

 

Hypoxic ischemic (HI) insults during pregnancy and birth can result in long term neurodevelopmental disorders, such as cerebral palsy. We have previously shown that human umbilical cord blood (hUCB) cells are effective at reducing neuroinflammation and improving brain injury in the short-term. In this current study we aimed to examine the long-term behavioural outcomes and neuropathology, specifically the beneficial effect of repeated doses of hUCB and different administration routes. Using a pre-clinical rodent model of HI, we showed that treatment with repeated doses of hUCB cells is more effective than a single dose for reducing long-term tissue damage and restoring behavioural deficits following perinatal brain injury. We hope this research will lead to improved clinical trial designs for the treatment of perinatal brain injury.

 

 
11:35 – 11:45 am Questions and Answers    
11:45 – 12:05 pm PRS Early Career Speaker – Amelie Collins, MD, PhD Title: Neonatal neutropenia is due to inadequate emergency  myelopoiesis at the level of fetal hematopoietic stem and progenitor cells. 

 

Neonates are uniquely susceptible to infection, with neonatal sepsis accounting for 1.4 million deaths annually worldwide. Unlike adults, in whom infection mobilizes a large pool of neutrophils from the bone marrow that are rapidly replenished by upstream progenitors, neonates often become neutropenic upon infection, resulting significant morbidity and mortality.  This presentation will focus on the mechanisms underpinning this divergence in activation of emergency myelopoiesis pathways at the level of hematopoietic stem cells, which is fundamental for understanding the differences in mortality and morbidity resulting from inflammation and infection at these developmentally disparate times of life.

 
12:05 – 12:15 pm Questions and Answers    
12:15 – 1:30 pm Lunch Break    
1:30 – 2:30 pm Business Meeting    
  Mead Johnson Nutrition  Early Career Speakers    
2:30 – 2:50 pm PRS Early Career Speaker – Swati Shree, MD  
2:50 – 3:00 pm Questions and Answers    
3:00 – 3:20 pm Mead Johnson Nutrition Early Career Speaker – Elizabeth Enninga, PhD Title: Mechanisms of tissue rejection in non-infectious placental villitis.

 

Between 15-30% of placentae are diagnosed with villitis of unknown etiology, which is characterized by the infiltration of CD8+ maternal immune cells and can lead to growth restriction and fetal demise.  Studies are under way to better define the function of these T cells and understand the mechanisms at the fetal-maternal interface that lead to this rejection type response.

 
3:20 – 3:30 pm Questions and Answers    
3:30 – 4:15 pm Liley Lectureship and Award Winner – Candice Fike, MD 

Title: Towards effective therapies for neonatal pulmonary hypertension: A bench to bedside Journey. Treatments for infants with pulmonary hypertension associated with chronic cardiopulmonary disorders remain inadequate.  The presentation will chronicle Dr. Fike’s “bench –to – bedside“ journey to develop safe, practical, and effective therapies for these therapies for these infants.

 
4:15 – 4:30 pm Questions and Answers    
5:00 pm Bus leaves for Weisman Art Museum 5:00pm    
9:00 pm Bus leaves Weisman Art Museum at 9:00pm    
Sunday, September 29
Time Speaker Title/brief description of topic Location
6:45 – 7:4 5am Breakfast    
8:00 – 8:45 am Mead Johnson Nutrition Speaker – Irina Burd, MD, PhD 

Title: Immunoperinatology: Placental determinants of neonatal health and disease

 
8:45 – 9:00 am Questions and Answers    
9:00 – 9:45 am Abbott Nutrition Speaker – Irina Buhimschi, MD  Title: Bridges and Bottlenecks over the Valley of Death in Perinatal Research

 

The “Valley of Death” metaphorically describes the gap between basic research discoveries and their applications in clinical practice. Over the past ten years, funding agencies have tried making the Valley of Death more navigable for academic researchers so that innovations can be more rapidly transitioned into useful interventions. This talk will examine three important problems in perinatal research: preeclampsia, preterm birth, and optimization of perinatal outcomes. Despite the overwhelming need to address these issues, diagnostic and therapeutic innovation has lagged behind other fields such as cancer, HIV, or cardiovascular research. Drawing from personal experiences, the presentation will review critical elements of successful translational science that are seldom discussed, including intellectual property, technology transfer, and partnerships for scale and sustainability.

 
9:45 – 10:00 am Questions and Answers    
10:00 – 10:15 am BREAK    
10:15 – 11:00 am Ferring PRS  Sponsored Member Speaker- 1  Trent E. Tipple,  MD Title:  Lost in Translation:  Bridging the Gap in Perinatal Redox Biology Research. 

 

Given the established role of oxidative stress in the pathobiology of perinatal diseases, the potential efficacy of redox-based therapeutic has been supported by numerous preclinical studies.  Unfortunately, these approaches have failed to translate into meaningful clinical therapies.  Using examples from his ongoing research, Dr. Tipple will demonstrate how sufficient appreciation of the complexities of redox biology, when coupled with realistic modeling of clinical scenarios, can bridge the bench to bedside gap in perinatal redox biology.

 
11:00 – 11:15 am Questions and Answers    
11:15 – 12:00 pm  Ferring PRS Sponsored Member Speaker 2 –   Emily J. Su, MD

Title:  Mediators of impaired fetoplacental angiogenesis in severe fetal growth restriction.  Abnormal umbilical artery Doppler velocimetry in growth-restricted fetuses is an ominous finding that substantially increases risk for adverse perinatal and long-term outcomes. Impaired placental angiogenesis resulting in abnormally thin, unbranched villous vessels is a common pathologic finding in the pregnancies  and is a structural cause of aberrantly elevated fetoplacental vascular resistance.  In a model of human fetoplancetalendothelial cells, we have found various mechanisms that underlie deficient angiogenesis in severe fetal growth restriction.

 
12:00 – 12:15pm Questions and Answers    
12:30 pm Closing remarks, Adjournment, Lunch    
             

 

2019 Annual Meeting Memories