Meeting Program 2019

50th Annual PRS Meeting - September 27-29, 2019 (Workshop September 25-27)

Minneapolis Marriott Northwest

7025 Northland Drive North, Brooklyn Park, MN

Overall Meeting Theme(s)

  1. “Bench to Bedside” – the continuum of research contributions from PRS members
  2. Celebrate the success of the Society over 50 years

General Layout

Friday Night -Dinner & Speaker


Time Speaker Title/brief description of topic Location
530 pm Welcome Reception Followed by Dinner
7:00pm Welcome by PRS President Lisa Joss-Moore, PhD
7:30pm NICHD Presentation A moderated presentation celebrating the Perinatal Research Society, its first 50 years, and the future
Saturday, Sept 28, 2019
Time Speaker Title/brief description of topic Location
6:45 – 7:45am Breakfast  
8:00 – 8:45am University of Utah OB Speaker   - Sandra T. Davidge, PhD, FAAP Title: Impact of pregnancy complications on later life cardiovascular health in the offspring- what can we do about it?”

Pregnancy is a window to assess cardiovascular health and can impact later-life maternal and offspring cardiovascular health, thus impacting future generations. Dr. Davidge’s research is focused on understanding mechanisms for vascular complications of pregnancy (e.g. preeclampsia, maternal aging) and developmental origins of cardiovascular disease. The impact of this research is to ultimately develop novel therapeutic strategies to improve pregnancy outcomes and minimize the impact of pregnancy complications on both maternal and offspring cardiovascular health.

8:45 – 9:00am Questions and Answers  
9:00 – 9:45am University of Utah Pediatrics Speaker – David Stevenson, MD Title: Understanding Disparities in Preterm Birth.  "New insights into the immunologic and signaling processes that determine gestational length in pregnancy have revealed important complexity in the interactions (ancestral and current) between genetic and environmental forces.  A better understanding of these relationships could guide research efforts which, in turn, could lead to a reduction in disparities in preterm birth by introducing effective clinical and public health interventions."   
9:45 – 10:00am Questions and Answers    
10:00 – 10:15am BREAK  
10:15 – 11:00am March of Dimes Speaker – Patrick Catalano, MD Title: Maternal obesity and gestational diabetes; short and long term effects on the offspring.  Maternal obesity and diabetes have independent effects on fetal growth.  Long-term, maternal gestational diabetes is associated primarily with childhood glucose metabolism, while maternal obesity is primarily associated with childhood adiposity.
11:00 – 11:15am Questions and Answers  
Abbott Nutrition Early Career Speakers  

11:15 – 11:35am

PRS-PSANZ Early Career Speaker - Tayla Penny  Title:  Repeated doses of umbilical cord blood cells modulate perinatal brain injury.

Hypoxic ischemic (HI) insults during pregnancy and birth can result in long term neurodevelopmental disorders, such as cerebral palsy. We have previously shown that human umbilical cord blood (hUCB) cells are effective at reducing neuroinflammation and improving brain injury in the short-term. In this current study we aimed to examine the long-term behavioural outcomes and neuropathology, specifically the beneficial effect of repeated doses of hUCB and different administration routes. Using a pre-clinical rodent model of HI, we showed that treatment with repeated doses of hUCB cells is more effective than a single dose for reducing long-term tissue damage and restoring behavioural deficits following perinatal brain injury. We hope this research will lead to improved clinical trial designs for the treatment of perinatal brain injury.

11:35 – 11:45am Questions and Answers  
11:45 – 12:05pm PRS Early Career Speaker (1)  
12:05 – 12:15pm Questions and Answers  
12:15 – 1:30pm Lunch Break  
1:30 – 2:30pm Business Meeting  
Mead Johnson Nutrition  Early Career Speakers  
2:30 – 2:50pm PRS Early Career Speaker (2)
2:50 – 3:00pm Questions and Answers
3:00 – 3:20pm Mead Johnson Nutrition Early Career Speaker (3) -
3:20 – 3:30pm Questions and Answers
3:30 – 4:15pm Liley Award Winner - Candice Fike MD  Title: Towards effective therapies for neonatal pulmonary hypertension: A bench to bedside Journey. Treatments for infants with pulmonary hypertension associated with chronic cardiopulmonary disorders remain inadequate.  The presentation will chronicle Dr. Fike’s “bench –to - bedside-“ journey to develop safe, practical, and effective therapies for these therapies for these infants.
4:15 – 4:30pm Questions and Answers
5:00pm Bus leaves for Weisman Art Museum 5:00pm
9:00pm Bus leaves Weisman Art Museum at 9:00pm
Sun Morning: September
Time Speaker Title/brief description of topic Location
6:45 – 7:45am Breakfast  
8:00 – 8:45am Mead Johnson Nutrition Speaker – Irina Burd MD PhD  Title: Immunoperinatology: Placental determinants of neonatal health and disease
8:45 – 9:00am Questions and Answers
9:00 – 9:45am Abbott Nutrition Speaker - Irina Buhimschi, MD  Title: Bridges and Bottlenecks over the Valley of Death in Perinatal Research

The “Valley of Death” metaphorically describes the gap between basic research discoveries and their applications in clinical practice. Over the past ten years, funding agencies have tried making the Valley of Death more navigable for academic researchers so that innovations can be more rapidly transitioned into useful interventions. This talk will examine three important problems in perinatal research: preeclampsia, preterm birth, and optimization of perinatal outcomes. Despite the overwhelming need to address these issues, diagnostic and therapeutic innovation has lagged behind other fields such as cancer, HIV, or cardiovascular research. Drawing from personal experiences, the presentation will review critical elements of successful translational science that are seldom discussed, including intellectual property, technology transfer, and partnerships for scale and sustainability.

9:45 – 10:00am Questions and Answers
10:00 – 10:15am BREAK
10:15 – 11:00am Ferring PRS  Sponsored Member Speaker- 1 Trent E. Tipple  MD Title:  Lost in Translation:  Bridging the Gap in Perinatal Redox Biology Research. 

Given the established role of oxidative stress in the pathobiology of perinatal diseases, the potential efficacy of redox-based therapeutic has been supported by numerous preclinical studies.  Unfortunately, these approaches have failed to translate into meaningful clinical therapies.  Using examples from his ongoing research, Dr. Tipple will demonstrate how sufficient appreciation of the complexities of redox biology, when coupled with realistic modeling of clinical scenarios, can bridge the bench to bedside gap in perinatal redox biology.

11:00 – 11:15am Questions and Answers
11:15 – 12:00pm  Ferring PRS Sponsored Member Speaker 2 -   Emily J. Su MD Title:  Mediators of impaired fetoplacental angiogenesis in severe fetal growth restriction.  Abnormal umbilical artery Doppler velocimetry in growth-restricted fetuses is an ominous finding that substantially increases risk for adverse perinatal and long-term outcomes. Impaired placental angiogenesis resulting in abnormally thin, unbranched villous vessels is a common pathologic finding in the pregnancies  and is a structural cause of aberrantly elevated fetoplacental vascular resistance.  In a model of human fetoplancetalendothelial cells, we have found various mechanisms that underlie deficient angiogenesis in severe fetal growth restriction.
12:00 – 12:15pm Questions and Answers
12:30pm Closing remarks, Adjournment, Lunch

Meeting Registration 2019