Meeting Program 2019

“Bench to Bedside: the continuum of research contributions from PRS members”

50th Annual Meeting

September 27-29, 2019
Minneapolis Marriott Northwest
Brooklyn Park, MN

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Friday, September 27 – Dinner & Speaker
Time Speaker Title/brief description of topic Location
3:00 – 6:00 pm   CHECK-IN AND REGISTRATION  
530 pm Welcome Reception Followed by Dinner    
7:00 pm Welcome by PRS President Lisa Joss-Moore, PhD  
7:30 pm NICHD Presentation A moderated presentation celebrating the Perinatal Research Society, its first 50 years, and the future  

Saturday, September 28

Time Speaker Title/brief description of topic Location
6:45 – 7:45 am Breakfast    
8:00 – 8:45 am University of Utah OB Speaker   – Sandra T. Davidge, PhD, FAAP Title: Impact of pregnancy complications on later life cardiovascular health in the offspring- what can we do about it?”

Pregnancy is a window to assess cardiovascular health and can impact later-life maternal and offspring cardiovascular health, thus impacting future generations. Dr. Davidge’s research is focused on understanding mechanisms for vascular complications of pregnancy (e.g. preeclampsia, maternal aging) and developmental origins of cardiovascular disease. The impact of this research is to ultimately develop novel therapeutic strategies to improve pregnancy outcomes and minimize the impact of pregnancy complications on both maternal and offspring cardiovascular health.

8:45 – 9:00 am Questions and Answers    
9:00 – 9:45 am University of Utah Pediatrics Speaker – David Stevenson, MD

Title: Understanding Disparities in Preterm Birth.  “New insights into the immunologic and signaling processes that determine gestational length in pregnancy have revealed important complexity in the interactions (ancestral and current) between genetic and environmental forces.  A better understanding of these relationships could guide research efforts which, in turn, could lead to a reduction in disparities in preterm birth by introducing effective clinical and public health interventions.” 

9:45 – 10:00 am Questions and Answers    
10:00 – 10:15 am BREAK    
10:15 – 11:00 am March of Dimes Speaker – Patrick Catalano, MD

Title: Maternal obesity and gestational diabetes; short and long term effects on the offspring.  Maternal obesity and diabetes have independent effects on fetal growth.  Long-term, maternal gestational diabetes is associated primarily with childhood glucose metabolism, while maternal obesity is primarily associated with childhood adiposity.

11:00 – 11:15 am Questions and Answers    
  Abbott Nutrition Early Career Speakers    

11:15 – 11:35 am

PRS-PSANZ Early Career Speaker – Tayla Penny  Title:  Repeated doses of umbilical cord blood cells modulate perinatal brain injury.

Hypoxic ischemic (HI) insults during pregnancy and birth can result in long term neurodevelopmental disorders, such as cerebral palsy. We have previously shown that human umbilical cord blood (hUCB) cells are effective at reducing neuroinflammation and improving brain injury in the short-term. In this current study we aimed to examine the long-term behavioural outcomes and neuropathology, specifically the beneficial effect of repeated doses of hUCB and different administration routes. Using a pre-clinical rodent model of HI, we showed that treatment with repeated doses of hUCB cells is more effective than a single dose for reducing long-term tissue damage and restoring behavioural deficits following perinatal brain injury. We hope this research will lead to improved clinical trial designs for the treatment of perinatal brain injury.

11:35 – 11:45 am Questions and Answers    
11:45 – 12:05 pm PRS Early Career Speaker – Amelie Collins, MD, PhD Title: Neonatal neutropenia is due to inadequate emergency  myelopoiesis at the level of fetal hematopoietic stem and progenitor cells. 

Neonates are uniquely susceptible to infection, with neonatal sepsis accounting for 1.4 million deaths annually worldwide. Unlike adults, in whom infection mobilizes a large pool of neutrophils from the bone marrow that are rapidly replenished by upstream progenitors, neonates often become neutropenic upon infection, resulting significant morbidity and mortality.  This presentation will focus on the mechanisms underpinning this divergence in activation of emergency myelopoiesis pathways at the level of hematopoietic stem cells, which is fundamental for understanding the differences in mortality and morbidity resulting from inflammation and infection at these developmentally disparate times of life.

12:05 – 12:15 pm Questions and Answers    
12:15 – 1:30 pm Lunch Break    
1:30 – 2:30 pm Business Meeting    
  Mead Johnson Nutrition  Early Career Speakers    
2:30 – 2:50 pm PRS Early Career Speaker – Swati Shree, MD  
2:50 – 3:00 pm Questions and Answers    
3:00 – 3:20 pm Mead Johnson Nutrition Early Career Speaker – Elizabeth Enninga, PhD Title: Mechanisms of tissue rejection in non-infectious placental villitis.

Between 15-30% of placentae are diagnosed with villitis of unknown etiology, which is characterized by the infiltration of CD8+ maternal immune cells and can lead to growth restriction and fetal demise.  Studies are under way to better define the function of these T cells and understand the mechanisms at the fetal-maternal interface that lead to this rejection type response.

3:20 – 3:30 pm Questions and Answers    
3:30 – 4:15 pm Liley Lectureship and Award Winner – Candice Fike, MD 

Title: Towards effective therapies for neonatal pulmonary hypertension: A bench to bedside Journey. Treatments for infants with pulmonary hypertension associated with chronic cardiopulmonary disorders remain inadequate.  The presentation will chronicle Dr. Fike’s “bench –to – bedside“ journey to develop safe, practical, and effective therapies for these therapies for these infants.

4:15 – 4:30 pm Questions and Answers    
5:00 pm Bus leaves for Weisman Art Museum 5:00pm    
9:00 pm Bus leaves Weisman Art Museum at 9:00pm    
Sunday, September 29
Time Speaker Title/brief description of topic Location
6:45 – 7:4 5am Breakfast    
8:00 – 8:45 am Mead Johnson Nutrition Speaker – Irina Burd, MD, PhD 

Title: Immunoperinatology: Placental determinants of neonatal health and disease

8:45 – 9:00 am Questions and Answers    
9:00 – 9:45 am Abbott Nutrition Speaker – Irina Buhimschi, MD  Title: Bridges and Bottlenecks over the Valley of Death in Perinatal Research

The “Valley of Death” metaphorically describes the gap between basic research discoveries and their applications in clinical practice. Over the past ten years, funding agencies have tried making the Valley of Death more navigable for academic researchers so that innovations can be more rapidly transitioned into useful interventions. This talk will examine three important problems in perinatal research: preeclampsia, preterm birth, and optimization of perinatal outcomes. Despite the overwhelming need to address these issues, diagnostic and therapeutic innovation has lagged behind other fields such as cancer, HIV, or cardiovascular research. Drawing from personal experiences, the presentation will review critical elements of successful translational science that are seldom discussed, including intellectual property, technology transfer, and partnerships for scale and sustainability.

9:45 – 10:00 am Questions and Answers    
10:00 – 10:15 am BREAK    
10:15 – 11:00 am Ferring PRS  Sponsored Member Speaker- 1  Trent E. Tipple,  MD Title:  Lost in Translation:  Bridging the Gap in Perinatal Redox Biology Research. 

Given the established role of oxidative stress in the pathobiology of perinatal diseases, the potential efficacy of redox-based therapeutic has been supported by numerous preclinical studies.  Unfortunately, these approaches have failed to translate into meaningful clinical therapies.  Using examples from his ongoing research, Dr. Tipple will demonstrate how sufficient appreciation of the complexities of redox biology, when coupled with realistic modeling of clinical scenarios, can bridge the bench to bedside gap in perinatal redox biology.

11:00 – 11:15 am Questions and Answers    
11:15 – 12:00 pm  Ferring PRS Sponsored Member Speaker 2 –   Emily J. Su, MD

Title:  Mediators of impaired fetoplacental angiogenesis in severe fetal growth restriction.  Abnormal umbilical artery Doppler velocimetry in growth-restricted fetuses is an ominous finding that substantially increases risk for adverse perinatal and long-term outcomes. Impaired placental angiogenesis resulting in abnormally thin, unbranched villous vessels is a common pathologic finding in the pregnancies  and is a structural cause of aberrantly elevated fetoplacental vascular resistance.  In a model of human fetoplancetalendothelial cells, we have found various mechanisms that underlie deficient angiogenesis in severe fetal growth restriction.

12:00 – 12:15pm Questions and Answers    
12:30 pm Closing remarks, Adjournment, Lunch    

2019 Annual Meeting Memories