Author Archives: PRS

Meeting Program 2019

50th Annual Meeting

September 27-29, 2019

Minneapolis Marriott Northwest, Brooklyn Park, MN

Overall Meeting Theme(s)

  1. “Bench to Bedside” – the continuum of research contributions from PRS members
  2. Celebrate the success of the Society over 50 years
Friday, September 27 – Dinner & Speaker
Time Speaker Title/brief description of topic Location
3:00 – 6:00 pm   CHECK-IN AND REGISTRATION  
530 pm Welcome Reception Followed by Dinner    
7:00 pm Welcome by PRS President Lisa Joss-Moore, PhD  
7:30 pm NICHD Presentation A moderated presentation celebrating the Perinatal Research Society, its first 50 years, and the future  
       

Saturday, September 28

     
Time Speaker Title/brief description of topic Location
6:45 – 7:45 am Breakfast    
8:00 – 8:45 am University of Utah OB Speaker   – Sandra T. Davidge, PhD, FAAP Title: Impact of pregnancy complications on later life cardiovascular health in the offspring- what can we do about it?”

 

Pregnancy is a window to assess cardiovascular health and can impact later-life maternal and offspring cardiovascular health, thus impacting future generations. Dr. Davidge’s research is focused on understanding mechanisms for vascular complications of pregnancy (e.g. preeclampsia, maternal aging) and developmental origins of cardiovascular disease. The impact of this research is to ultimately develop novel therapeutic strategies to improve pregnancy outcomes and minimize the impact of pregnancy complications on both maternal and offspring cardiovascular health.

 
8:45 – 9:00 am Questions and Answers    
9:00 – 9:45 am University of Utah Pediatrics Speaker – David Stevenson, MD

Title: Understanding Disparities in Preterm Birth.  “New insights into the immunologic and signaling processes that determine gestational length in pregnancy have revealed important complexity in the interactions (ancestral and current) between genetic and environmental forces.  A better understanding of these relationships could guide research efforts which, in turn, could lead to a reduction in disparities in preterm birth by introducing effective clinical and public health interventions.” 

 

 
9:45 – 10:00 am Questions and Answers    
10:00 – 10:15 am BREAK    
10:15 – 11:00 am March of Dimes Speaker – Patrick Catalano, MD

Title: Maternal obesity and gestational diabetes; short and long term effects on the offspring.  Maternal obesity and diabetes have independent effects on fetal growth.  Long-term, maternal gestational diabetes is associated primarily with childhood glucose metabolism, while maternal obesity is primarily associated with childhood adiposity.

 
11:00 – 11:15 am Questions and Answers    
  Abbott Nutrition Early Career Speakers    
 

 

11:15 – 11:35 am

PRS-PSANZ Early Career Speaker – Tayla Penny  Title:  Repeated doses of umbilical cord blood cells modulate perinatal brain injury.

 

Hypoxic ischemic (HI) insults during pregnancy and birth can result in long term neurodevelopmental disorders, such as cerebral palsy. We have previously shown that human umbilical cord blood (hUCB) cells are effective at reducing neuroinflammation and improving brain injury in the short-term. In this current study we aimed to examine the long-term behavioural outcomes and neuropathology, specifically the beneficial effect of repeated doses of hUCB and different administration routes. Using a pre-clinical rodent model of HI, we showed that treatment with repeated doses of hUCB cells is more effective than a single dose for reducing long-term tissue damage and restoring behavioural deficits following perinatal brain injury. We hope this research will lead to improved clinical trial designs for the treatment of perinatal brain injury.

 

 
11:35 – 11:45 am Questions and Answers    
11:45 – 12:05 pm PRS Early Career Speaker – Amelie Collins, MD, PhD Title: Neonatal neutropenia is due to inadequate emergency  myelopoiesis at the level of fetal hematopoietic stem and progenitor cells. 

 

Neonates are uniquely susceptible to infection, with neonatal sepsis accounting for 1.4 million deaths annually worldwide. Unlike adults, in whom infection mobilizes a large pool of neutrophils from the bone marrow that are rapidly replenished by upstream progenitors, neonates often become neutropenic upon infection, resulting significant morbidity and mortality.  This presentation will focus on the mechanisms underpinning this divergence in activation of emergency myelopoiesis pathways at the level of hematopoietic stem cells, which is fundamental for understanding the differences in mortality and morbidity resulting from inflammation and infection at these developmentally disparate times of life.

 
12:05 – 12:15 pm Questions and Answers    
12:15 – 1:30 pm Lunch Break    
1:30 – 2:30 pm Business Meeting    
  Mead Johnson Nutrition  Early Career Speakers    
2:30 – 2:50 pm PRS Early Career Speaker – Swati Shree, MD  
2:50 – 3:00 pm Questions and Answers    
3:00 – 3:20 pm Mead Johnson Nutrition Early Career Speaker – Elizabeth Enninga, PhD Title: Mechanisms of tissue rejection in non-infectious placental villitis.

 

Between 15-30% of placentae are diagnosed with villitis of unknown etiology, which is characterized by the infiltration of CD8+ maternal immune cells and can lead to growth restriction and fetal demise.  Studies are under way to better define the function of these T cells and understand the mechanisms at the fetal-maternal interface that lead to this rejection type response.

 
3:20 – 3:30 pm Questions and Answers    
3:30 – 4:15 pm Liley Lectureship and Award Winner – Candice Fike, MD 

Title: Towards effective therapies for neonatal pulmonary hypertension: A bench to bedside Journey. Treatments for infants with pulmonary hypertension associated with chronic cardiopulmonary disorders remain inadequate.  The presentation will chronicle Dr. Fike’s “bench –to – bedside“ journey to develop safe, practical, and effective therapies for these therapies for these infants.

 
4:15 – 4:30 pm Questions and Answers    
5:00 pm Bus leaves for Weisman Art Museum 5:00pm    
9:00 pm Bus leaves Weisman Art Museum at 9:00pm    
Sunday, September 29
Time Speaker Title/brief description of topic Location
6:45 – 7:4 5am Breakfast    
8:00 – 8:45 am Mead Johnson Nutrition Speaker – Irina Burd, MD, PhD 

Title: Immunoperinatology: Placental determinants of neonatal health and disease

 
8:45 – 9:00 am Questions and Answers    
9:00 – 9:45 am Abbott Nutrition Speaker – Irina Buhimschi, MD  Title: Bridges and Bottlenecks over the Valley of Death in Perinatal Research

 

The “Valley of Death” metaphorically describes the gap between basic research discoveries and their applications in clinical practice. Over the past ten years, funding agencies have tried making the Valley of Death more navigable for academic researchers so that innovations can be more rapidly transitioned into useful interventions. This talk will examine three important problems in perinatal research: preeclampsia, preterm birth, and optimization of perinatal outcomes. Despite the overwhelming need to address these issues, diagnostic and therapeutic innovation has lagged behind other fields such as cancer, HIV, or cardiovascular research. Drawing from personal experiences, the presentation will review critical elements of successful translational science that are seldom discussed, including intellectual property, technology transfer, and partnerships for scale and sustainability.

 
9:45 – 10:00 am Questions and Answers    
10:00 – 10:15 am BREAK    
10:15 – 11:00 am Ferring PRS  Sponsored Member Speaker- 1  Trent E. Tipple,  MD Title:  Lost in Translation:  Bridging the Gap in Perinatal Redox Biology Research. 

 

Given the established role of oxidative stress in the pathobiology of perinatal diseases, the potential efficacy of redox-based therapeutic has been supported by numerous preclinical studies.  Unfortunately, these approaches have failed to translate into meaningful clinical therapies.  Using examples from his ongoing research, Dr. Tipple will demonstrate how sufficient appreciation of the complexities of redox biology, when coupled with realistic modeling of clinical scenarios, can bridge the bench to bedside gap in perinatal redox biology.

 
11:00 – 11:15 am Questions and Answers    
11:15 – 12:00 pm  Ferring PRS Sponsored Member Speaker 2 –   Emily J. Su, MD

Title:  Mediators of impaired fetoplacental angiogenesis in severe fetal growth restriction.  Abnormal umbilical artery Doppler velocimetry in growth-restricted fetuses is an ominous finding that substantially increases risk for adverse perinatal and long-term outcomes. Impaired placental angiogenesis resulting in abnormally thin, unbranched villous vessels is a common pathologic finding in the pregnancies  and is a structural cause of aberrantly elevated fetoplacental vascular resistance.  In a model of human fetoplancetalendothelial cells, we have found various mechanisms that underlie deficient angiogenesis in severe fetal growth restriction.

 
12:00 – 12:15pm Questions and Answers    
12:30 pm Closing remarks, Adjournment, Lunch    
             

 

2019 Annual Meeting Memories

Meeting Program 2018

49th Annual Meeting

September 7 – 9, 2018
Hilton Inverness Hotel and Conference Center, Englewood, CO

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Welcome – PRS President, Jeff Reese, MD

Mead Johnson Nutrition Speaker

Jeff Alberts, PhD – Gravid Without Gravity: Spaceflight Experiments Yield Insights into Perinatal Development

Abbott Nutrition Speaker

David Keefe, MD – Preimplantation Genetic Testing – Past – Present and Future

Liley Lectureship and Award Winner

Jane Harding, ONZM MBCHB DPhi FRCPC FRSNZ –Glucose Levels in Babies: Too High – Too Low – Too Variable – and Does it Matter?

PSANZ-PRS Mont Liggins Early Career Speaker

Aidan James Kashyap – A Bundle of Care for Congenital Diaphragmatic Hernia – Bigger Lungs – Better Vessels – and a Smoother Transition

March of Dimes Speaker

Richard Finkel, MD – Genetic Modulation Strategies for Spinal Muscular Atrophy – Current and Future Treatments

NICHD Speaker

Stephen Kingsmore, MD, DSC – Perinatal Genomic Medicine

Vanderbilt Speaker

Sylvain Chemtob, MD, PhD, FRCPC, FAAP, FCAHS, FARVO – Discovery of New IL-1 Receptor – Modulator – Prevention of Preterm Labor and Preservation of Fetal Integrity

Mead Johnson Nutrition Early Career Speakers

Andrea Edlow, MD– Maternal Obesity and Fetal Inflammation: Brain-Placenta Crosstalk and Consequences Across the Lifespan

Heather Brockway, PhD – A Role for Placental Maturity in Idiopathic Spontaneous Preterm Birth

Abbott Nutrition Early Career Speakers

Brigid Gregg, MD –Lactational Programming of Offspring Insulin Resistance and Adiposity by Lactational High Fat Diet Exposure

Teresa Sparks, MD –Non-immune Hydrops Fetalis: Toward a Precision-based Approach

Invited Member Speakers

Thomas Jansson, MD, PhD – The Placenta and Life-long Health: How Understanding the Placenta Can Help Us Building Better Babies

Jennifer Sucre, MD, PhD –Bioengineering Human Lung Development and Disease

James Wynn, MD – Modifiable Determinants of Neurodevelopmental Impact in Neonatal Sepsis

Leadership 2018

President – Jeff Reese, MD

Secretary – Paul Rozance, MD

Memories from 2018 at the Hilton Inverness Hotel -Englewood, CO – Salsa Making Contest, Gathering with Colleague and Friends.

Meeting Program 2017

48th Annual Meeting

September 8 – 10, 2017 
Atlanta Marriott Buckhead Hotel and Conference Center

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Welcome  – PRS President Anthony Gregg, MD

Mead Johnson Nutrition Speaker

Erik Herzog, PhD – Circadan Regulation of Birth

Abbott Nutrition Speaker

Frank Bloomfield, MBChB, PhD – Fetal and Neonatal Nutrition and the Developing Pancreas

March of Dimes Speaker

Phyllis Dennery, MD – The Bioenergetics of Neonatal Lung Injury and Repair

NIH/NICHD Speaker

Diana Bianchi, MD, PRS Past President – A Vision of the Future of NICHD

NIH/NICHD Speaker

Dinesh Shaw, MD – Pathway to Preeclampsia

Liley Lectureship and Award Winners

Charles Wood, PhD and Maureen Keller-Wood, PhD – Using Systems Biology to Understand Maternal-Fetal Physiology

PSANZ-PRS Mont Liggins Early Career Speaker

Teresa MacDonald – The Fetal Longitudinal Assessment of Growth Study

Abbott Nutrition Early Career Speaker

Tomo Tarui, MD – Developing New Diagnostic Technologies for Fetal Neurological Disorders

Abbott Nutrition Early Career Speaker

Charitharth Vivek Lal, MD – The Role of Microbiota Induced Matrikines in Bronchopulmonary Dysplasia

Mead Johnson Nutrition Career Career Speakers

Leticia Camacho, PhD – Oxygen and Glucose Correction Improves Insulin Secretion in Sheep

Jennifer Thompson, PhD – Maternal Metabolic State and Cardiometabolic Risk in the Offspring

Invited Member Speakers

Clyde Wright, MD – Oxygen Toxicity in the Premature Lung. Can We Separate the Signal from the Inevitable Consequence?

Emin Maltepe, MD PhD – Using Sheep Models to Study Pulmonary Hypertension and Oxygen Delivery Biotherapeutics

Leadership 2017

President –Anthony Gregg, MD

Secretary -Treasurer – Paul Rozance, MD

Memories from 2017 – Atlanta Marriott Buckhead Hotel

Meeting Program 2016

47th Annual Meeting

September 23-25, 2016
Eaglewood Resort & Spa, Itasca, Illinois

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Welcome – PRS President, Ian Bird, PhD

Mead Johnson Nutrition Speaker

Alan Conley, BVSc, MS, PhD, FRCVS – Human Exceptionalism: Is It the Exception that Proves the Rule?

March of Dimes Speaker

Brian Cox, PhD –Genes – Placentas and Pathologies – a Multi-Scale Systems Biology Analysis

NICHD Placental Project

David Weinberg, PhD – The Human Placenta Project: Progress and Future Directions

Mead Johnson Nutrition Early Career Speakers

Kevin Johnson, PhD – Prospects for Monitoring Maternal-Fetal Disease using Advanced Quantative MR

Styliani Goulopoulous, PhD, MS – Hypertension in Pregnancy: Novel Mechanisms of Maternal Vascular Dysfunction

Abbott Nutrition Speaker

Jonathan M Fanaroff, MD, JD – Prevailing Ethical Issues in Fetal & Neonatal Care

Liley Lectureship and Award Winner

Kent L Thornburg, PhD – Women – Placentas – Babies: New Insights on the Origins of Human disease

PSANZ Early Career Speaker

Stacey Ellery, PhD – Is Creatine Transport and Synthesis Important for Human Placental Bioenergetics?

Abbott Nutrition Early Career Speakers

Arthur Vaught, MD – The Upregulation of the Alternative Pathway of Complement of HELLP Syndrome

Mary Robbins, MD – Role of MicroRNAs in Neonatal Lung Disease Models

NIH / NICHD Speaker

Gary D Hammer, MD, PhD – Translating Adrenal Stem Cells: Implications for Disease 

UW-Madision OGBYN Speaker

Laura L Hernandez, PhD – SSRIs: The Good and Potentially Ugly? Invited Associate Member Speaker

Invited Associate Member Speaker

Jill Maron, MD, MPH –Bringing Salivary Diagnostics to the Neonatal Bedside

Leadership 2016

President – Ian Bird, PhD

Secretary – Treasurer – Paul Rozance, MD

Memories from 2016 Meeting – Eaglewood Resort, Itasca, IL

Meeting Program 2015

46th Annual Meeting

September 18-20, 2015 
Inverness Hotel and Conference Center, Englewood, CO

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Welcome – PRS President Pamela Kling, MD

Mead Johnson Nutrition Speaker

Frances Northington, MD – A MFM and Neonatal Neuroscience Collaborative: A Natural Pairing to Advance the Prevention and Treatment of Neurologic Problems in the Newborn.

Abbott Nutrition Speaker

Benjamin Wilfond, MD – Research on Medical Practices: Rich – Consent and Relationship

March of Dimes Speaker

Anthony P. Auger, PhD – Epigenetic Programming of the Juvenile Social Brain: Is Biological Sex a Contributing Factor for Mental Health Risk?

University of Wisconsin/Meriter Member Speaker

Rebecca Simmons, MD – Developmental Programming of Adult Disease

Liley Lectureship and Award Winner

John A. Wildness, MD – Multi-Density Red Blood Cell Labeling with Biotin: A Pretty Cool-Safe-Versatile Method for Measuring Red Cell Volume

NIH/NICHD Speaker

Murray Brilliant, MD – Precision Medicine Research and Implementation

Johns Hopkins University Member Speaker

Laura Brown, MD – Brain vs Brawn: Insights into Fetal Skeletal Muscle Growth Restriction

Ohio State University/Nationwide Children’s Hospital Member Speaker

Jeff Reese, MD – Real-time In Vivo Detection of Biochemical changes in the Cervix During Pregnancy Using Raman Spectroscopy: A Novel Tool for Prediction of PTB

PSANZ-PRS Mont Liggins Early Career Investigator

Elisha Josev – Cerebellar-Cortical Connectivity in the Extremely Preterm Brain and its Contribution to Working Memory

Abbott Nutritional Early Career Speakers

Nicole G. Barra, PhD – Nicotine Use During Pregnancy: Predisposing Infants to Metabolic Diseases

Michelle L.. Baack, MD – The Short and Long-Term Consequences of Maternal Diabetes and High-Fat Diet on the Developing Heart

Mead Johnson Nutrition Early Career Speakers

Aleksandar Stanic, MD, PhD – The Role of Innate Lymphoid Cells in Normal and Preeclamptic Pregnancy

David McCulley, PhD – A Genetic Model of Congenital Diaphragmatic Hernia

Leadership 2015

President – Pamela Kling, MD

Secretary-Treasurer – Paul Rozance, MD

Memories from 2015 Meeting – Inverness Hotel, Englewood, CO